USDA-APHIS Determines Yield10 Biosciences Omega-3 Camelina Varieties May Be Planted and Raised in the United States

-Yield10 achieves major milestone enabling commercial-scale production of omega-3 fatty acids at Camelina

-Omega-3 Camelina potentially represents a new solution to the market need for omega-3 oils used in aquatic feed for farmed fish and in human nutrition.

WOBURN, Mass., March 21, 2024 (GLOBE NEWSWIRE) — Yield10 Bioscience, Inc. (Nasdaq:YTEN) (Yield10 or the Company), an agricultural bioscience company, announced today that the USDA-APHIS Biotechnology Regulatory Services (BRS) has determined that Yield10s Camelina sativa Varieties (“Camelina”) developed through genetic engineering (modified Camelina) to produce omega-3 fatty acids are not subject to 7 CFR part 340 regulations, and may be grown and raised in the United States. The global markets for omega-3 fatty acids include aquatic feed used for salmon and trout farming, pet feed, infant formula, nutraceuticals and pharmaceuticals. Most omega-3 fatty acids are produced from fish caught in the ocean. Production limitations and supply volatility of traditional sources of fish oil are creating supply gaps and driving increasing demand for new sources of omega-3. Using Camelina as a terrestrial production platform has the potential to provide a new and reliable supply of omega-3 fatty acids. Yield10s submissions along with USDA-APHIS BRS responses are posted on the USDA website.

This regulatory milestone represents a critical step in enabling increased commercial-scale planting of Camelina in the United States to produce omega-3 oil for key markets, including aquatic food and human nutrition, said Kristi Snell, Ph. D., scientific director of Yield10 Bioscience. In 2024, we plan to focus on executing our development program, building seed inventory in anticipation of commercial-scale planting, and engaging with potential business partners to enable commercial sale of omega-3 oil and meal to target markets. Use of omega-3 oil in the target markets may still be subject to regulation by other regulatory authorities in the target geographies.

In 2023, Yield10 submitted two regulatory status review (RSR) requests to the BRS under the SECURE rule (see below). An RSR submitted in July 2023 covers Camelina engineered to produce eicosapentaenoic acid (EPA) where engineered Omega-3 Camelina produces oil. which contains approximately 16-20% EPA. An RSR submitted in December 2023 covers the production of both EPA and docosahexaenoic acid (DHA) in which engineered Camelina omega-3 produces oil containing approximately 10% EPA and 10% DHA, very similar in the northern EPA/DHA omega-3 fatty acid profile. hemisphere fish oil. The USDA-APHIS responses indicate that the agency does not consider modified Camelina plants to be an increased plant pest risk compared to unmodified Camelina and are therefore not subject to regulation by the USDA-APHIS. 7 CFR part 340.

Background on the Yield10s Omega-3 Camelina program

Currently, the primary source of the essential fatty acids EPA and DHA is ocean-caught fish, with omega-3 oil produced from the anchovy harvest serving as the industry benchmark. The production of omega-3 fatty acids in Camelina represents a potential way to enable a reliable supply of high-quality omega-3 oils to meet the global demand for EPA and DHA. In 2020, Yield10 signed a collaboration agreement with Rothamsted to support Rothamsteds flagship program to develop omega-3 oils in Camelina. As part of the collaboration agreement, the company received an exclusive option to enter into a global and exclusive license agreement for the technology. In October 2023, Yield10 announced that it had exercised this option and plans to terminate the global commercial license with Rothamsted. Subsequently, Yield10 and BioMar Group, a global aquatic food producer, signed a Letter of Intent (LOI) to form a long-term partnership to commercialize a Camelina culture containing enriched levels of EPA and DHA equal to the fish oil

In 2024, Yield10 plans to work with BioMar Group to sign a collaboration agreement. In addition, Yield10 plans to continue field trials and seed expansion activities for its Camelina omega-3 varieties designed to increase the seed inventory for future plantings as well as produce omega-3 oil for use in business development activities. Yield10 is also designing second-generation Camelina omega-3 lines with herbicide tolerance traits to enable weed control in large-scale commercial planting of the crop.

About the SAFE rule

The SECURE rule was published on May 18, 2020, and represents the first comprehensive revision of APHIS biotechnology regulations since 1987. The revisions allow APHIS to regulate genetically engineered organisms for plant pest risk more precisely and reduces the regulatory burden on organism developers. which are unlikely to pose risks to plant pests. Once a specific plant developed through genetic engineering is found to not require regulation, new varieties of the plant containing the same genetic modification would also not be regulated. Camelina plants that contain omega-3 traits are subject to regulation by the US Food and Drug Administration.

about Yield10 Bioscience

Yield10 Bioscience, Inc. (“Yield10” or “the Company”) is an agricultural bioscience company that leverages advanced genetics to develop oilseeds Camelina sativa (“Camelina”) as a platform crop for the large-scale production of sustainable seed products. These seed products include feedstock oils for renewable diesel and sustainable aviation biofuels; omega-3 oils (EPA and DHA+EPA) for pharmaceutical, nutraceutical and aquafeed applications; and, in the future, PHA biomaterials for use as biodegradable bioplastics. Subject to the availability of sufficient financial resources to continue operations, our business plan is based on establishing a grain procurement business leveraging our elite Camelina seed varieties, focusing on the production of omega- 3 for nutritional applications and partner or license our advanced Camelina. genetic technologies to biofuel value chain partners to support their goals of meeting the growing demand for low-carbon feedstock oil. Yield10 is headquartered in Woburn, MA and has a Canadian subsidiary, Yield10 Oilseeds Inc., located in Saskatoon, Canada.

For more information about the company, visit www.yield10bio.com or follow the company onX (formerly Twitter), Facebook and LinkedIn.

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Safe harbor for looking ahead Declarations

This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements in this release do not constitute guarantees of future performance. Investors are cautioned that statements in this press release that are not strictly historical, including, without limitation, statements about Omega-3 Camelina’s ability and technology being developed to provide sustainable alternatives to media existing omega-3 oil production, expectations regarding regulatory approval for commercial production of Yield10s Camelina product lines, reliability, scalability and addressable market for omega-3 oils produced in from Camelina omega-3 and collaborations with potential strategic partners, including the planned completion of the global commercial license under the agreement with Rothamsted and the signing of an agreement with BioMar, constitute forward-looking statements. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including, but not limited to, the Company’s ability to obtain adequate short-term financing to continue operations and continue to be listed. on the Nasdaq stock market, about which no assurance can be given, as well as the risks and uncertainties detailed in Yield10 Bioscience’s filings with the Securities and Exchange Commission. Yield10 undertakes no obligation to update any forward-looking information contained in this press release or with respect to the matters described herein.

Contacts:
Yield10 Bioscience:
Lynne H. Brum, (617) 682-4693, LBrum@yield10bio.com

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