The natural molecule increases NAD+ levels, improving muscle function during aging

Trigonellin, which can be found in coffee, decreases during sarcopenia, but increasing its levels can improve physical performance.

Sarcopenia, a condition characterized by the progressive loss of skeletal muscle mass and function, poses a substantial global health challenge, particularly among the growing elderly population.

Now, recent research by Nestl Research in Switzerland and the Yong Loo Lin School of Medicine at the National University of Singapore (NUS Medicine), in collaboration with other academic institutions, illuminates a possible therapeutic pathway involving the natural molecule of trigonelline [1]. Trigonella, which is found in the body, is also available from dietary sources such as coffee and fenugreek seeds.

Longevity.Technology: Central to the pathophysiology of sarcopenia are cellular alterations associated with aging, including decreased mitochondrial function and decreased levels of nicotinamide adenine dinucleotide (NAD+). These changes contribute to the deterioration of muscle tissue and functional decline, and most importantly, the research consortium identified a correlation between reduced levels of trigonelline and sarcopenia in aging individuals.

In preclinical models, administration of trigonelline demonstrated efficacy in mitigating aspects of sarcopenia. Specifically, trigonelline supplementation resulted in elevated NAD+ levels, enhanced mitochondrial activity, and preservation of muscle function. These findings, the authors say, suggest that nutritional supplementation of trigonelline could serve as an NAD + boosting strategy that works to attenuate age-related muscle decline. [1].

The natural molecule increases NAD+ levels, improving muscle function during aging
Trigonelline (upper bubble) has been found to decrease during sarcopenia. It may improve physical performance during aging by improving NAD+ levels (middle bubble) and mitochondrial activity (lower bubble).

Research also showed that supplementation with trigonelline C elegans was associated with improved mitochondrial respiration and biogenesis, reduced muscle wasting, and increased lifespan and mobility in animal models, mediated by an NAD + -dependent mechanism involving sirtuin pathways. Supplementing the diets of male mice with trigonelline improved their muscle strength and prevented fatigue during aging. [1].

The research findings underscore the therapeutic potential of trigonelline supplementation to address sarcopenia. While going to Starbucks won’t help in the short term, trigonelline offers a promising avenue for intervening against age-related muscle decline. In addition, the identification of trigonelline as a modulator of NAD+ levels highlights its importance in cellular metabolism and aging processes.

Assistant Professor Vincenzo Sorrentino from NUS Medicine’s Healthy Longevity Translational Research Program and corresponding author of the paper said: Our findings extend the current understanding of NAD+ metabolism with the discovery of trigonelline as a new precursor of NAD + and increase the potential to establish interventions with NAD + -Production of vitamins for both healthy longevity and age-related disease applications [2].

Diet and physical activity are important lifestyle recommendations for maintaining healthy muscles as you age. We were excited to discover through collaborative research that a natural molecule in food intersects with cellular characteristics of aging. The benefits of trigonelline on cellular metabolism and muscle health during aging open up promising translational applications, said Jerome Feige, Head of Physical Health at Nestl Research. [2].

Sarcopenia represents a significant global health burden, with profound implications for both individual well-being and healthcare systems worldwide. The discovery of trigonellin’s role in modulating cellular pathways associated with sarcopenia opens the door to a potential means of intervention, and further research elucidating the precise mechanisms of trigonellin action is warranted. ¬∑line and its clinical utility. Coffee flavored fenugreek seeds, anyone?

Image courtesy of Yong Loo Lin School of Medicine, NUS


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